Article
Induction of the heat shock regulon in response to increased mistranslation requires oxidative modification of the malformed proteins.
Molecular microbiology - 1 Jan 2006
Fredriksson Asa, Ballesteros Manuel, Dukan Sam, Nyström Thomas
Abstract excerpt
The Escherichia coli rpsD12 allele, which reduces translational fidelity and elevates expression of heat shock protein (Hsp) genes, only enhanced Hsp gene expression in the presence of oxygen. Similarly, the rpsL141 allele, which reduces mistranslation and Hsp gene expression, failed to affect the Hsp regulon in cells grown anaerobically. Increased production of Hsps in response to starvation is associated with...
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