Association of major depression with rare functional variants in norepinephrine transporter and serotonin1A receptor genes.

doi:10.1002/ajmg.b.30912

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Article

Association of major depression with rare functional variants in norepinephrine transporter and serotonin1A receptor genes.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Oct 2009

Haenisch Britta, Linsel Karoline, Brüss Michael, Gilsbach Ralf, Propping Peter, Nöthen Markus M, Rietschel Marcella, Fimmers Rolf, Maier Wolfgang, Zobel Astrid, Höfels Susanne, Guttenthaler Vera, Göthert Manfred, Bönisch Heinz

Abstract excerpt

Dysregulations of central noradrenergic and serotonergic neurotransmission have been suggested to contribute to the pathogenesis of neuropsychiatric disorders such as depression. The norepinephrine transporter (NET; SLC6A2) and the serotonin (5-HT)(1A) receptor (5-HT(1A) receptor; HTR1A) play an important role in central nervous monoaminergic homeostasis. As shown previously, variations in the human NET and...

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PMID: 19105200
DOI: 10.1002/ajmg.b.30912

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