Exploring sex differences in endocannabinoid system biomarkers and their relationship with antidepressant treatment outcomes in major depressive disorder: a CAN-BIND 1 secondary analysis.

doi:10.1007/s00406-026-02362-3

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Exploring sex differences in endocannabinoid system biomarkers and their relationship with antidepressant treatment outcomes in major depressive disorder: a CAN-BIND 1 secondary analysis.

European archives of psychiatry and clinical neuroscience - 1 Oct 2026

Sorkhou Maryam, Kim Helena K, Farzan Faranak, Foster Jane A, Frey Benicio N, Husain Muhammad I, Kennedy Sidney H, Lam Raymond W, Milev Roumen, Mulsant Benoit H, Müller Daniel J, Quilty Lena C, Soares Claudio N, Taylor Valerie H, Turecki Gustavo, Kloiber Stefan

Abstract excerpt

BACKGROUND: Sex differences in major depressive disorder (MDD) are well documented, but it remains unclear whether sex-related variation in peripheral endocannabinoid system (ECS)-related biomarkers is detectable in MDD. OBJECTIVES: To examine baseline sex differences in ECS-related mRNA expression, DNA methylation, and single nucleotide polymorphisms (SNPs) in MDD, and associations between baseline ECS markers...

Read the complete abstract on PubMed

Topics

Humans
Major Depressive Disorder
Male
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Endocannabinoids

Sex Characteristics

Polymorphism, Single Nucleotide

Treatment Effect Heterogeneity

Adult

Middle Aged

Antidepressive Agents

DNA Methylation

Biomarkers

RNA, Messenger

Escitalopram

Outcome Assessment, Health Care

Source

Open in PubMed

Identifiers

PMID: 42640306
DOI: 10.1007/s00406-026-02362-3

Genes

DAGLA
CACNA1H
GABRB2
GABRR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

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