Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Preferential 5-HT1A autoreceptor occupancy by pindolol is attenuated in depressed patients: effect of treatment or an endophenotype of depression?

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Sept 2004

Rabiner Eugenii A, Bhagwagar Zubin, Gunn Roger N, Cowen Philip J, Grasby Paul M

Abstract excerpt

Using positron emission tomography and the selective 5-HT1A receptor radioligand [11C]WAY100635, we previously demonstrated a preferential occupancy of 5-HT1A autoreceptors, compared to postsynaptic receptors by pindolol in healthy volunteers. We have speculated that preferential occupancy may be clinically important for the purported actions of pindolol in accelerating the antidepressant effects of selective...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenergic beta-Antagonists
Share to Depressive Disorder

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Psychiatric Status Rating Scales

Share to Pyridines

Share to Radiopharmaceuticals

Share to Receptor, Serotonin, 5-HT1A

Share to Serotonin Antagonists

Share to Tomography, Emission-Computed

Source

Identifiers

PMID: 15127080
DOI: 10.1038/sj.npp.1300472

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Preferential 5-HT1A autoreceptor occupancy by pindolol is attenuated in depressed patients: effect of treatment or an endophenotype of depression?PMID 15127080Read ↗

PET Imaging of the Serotonin 1A Receptor in Major Depressive Disorder: Hierarchical Multivariate Analysis of [ <sup>11</sup> C]WAY100635 Overcomes Outcome Measure DiscrepanciesSemantic proximity Read ↗

Serotonin receptors in depression: from A to BSemantic proximity Read ↗

Quantification of the Serotonin 1A Receptor Using PET: Identification of a Potential Biomarker of Major Depression in Males.Semantic proximity Read ↗

Understanding the molecular pharmacology of the serotonergic system: using fluoxetine as a model.Semantic proximity Read ↗

Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depression.Semantic proximity Read ↗

The structure of the serotonin system: A PET imaging studySemantic proximity Read ↗

A dual-receptor model of serotonergic psychedelicsSemantic proximity Read ↗

A Database of [11C]WAY-100635 Binding to 5-HT1A Receptors in Normal Male Volunteers: Normative Data and Relationship to Methodological, Demographic, Physiological, and Behavioral VariablesSemantic proximity Read ↗

Positron Emission Tomography (PET) Imaging Tracers for Serotonin ReceptorsSemantic proximity Read ↗

Elevated serotonin 1A binding in remitted major depressive disorder: evidence for a trait biological abnormality.Semantic proximity Read ↗

Different patterns of 5-HT receptor and transporter dysfunction in neuropsychiatric disorders – a comparative analysis of in vivo imaging findingsSemantic proximity Read ↗

Increased 5-HT <sub>2A</sub> receptor signalling efficacy differentiates serotonergic psychedelics from non-psychedelicsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.