Article
CNV Concordance in 1,097 MZ Twin Pairs.
Twin research and human genetics : the official journal of the International Society for Twin Studies - 1 Feb 2015
Abdellaoui Abdel, Ehli Erik A, Hottenga Jouke-Jan, Weber Zachary, Mbarek Hamdi, Willemsen Gonneke, van Beijsterveldt Toos, Brooks Andrew, Hudziak Jim J, Sullivan Patrick F, de Geus Eco J, Davies Gareth E, Boomsma Dorret I
Abstract excerpt
Monozygotic (MZ) twins are genetically identical at conception, making them informative subjects for studies on somatic mutations. Copy number variants (CNVs) are responsible for a substantial part of genetic variation, have relatively high mutation rates, and are likely to be involved in phenotypic variation. We conducted a genome-wide survey for post-twinning de novo CNVs in 1,097 MZ twin pairs. Comparisons...
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