Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles.

doi:10.1016/j.ajhg.2007.12.011

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles.

American journal of human genetics - 1 Mar 2008

Bruder Carl E G, Piotrowski Arkadiusz, Gijsbers Antoinet A C J, Andersson Robin, Erickson Stephen, Diaz de Ståhl Teresita, Menzel Uwe, Sandgren Johanna, von Tell Desiree, Poplawski Andrzej, Crowley Michael, Crasto Chiquito, Partridge E Christopher, Tiwari Hemant, Allison David B, Komorowski Jan, van Ommen Gert-Jan B, Boomsma Dorret I, Pedersen Nancy L, den Dunnen Johan T, Wirdefeldt Karin, Dumanski Jan P

Abstract excerpt

The exploration of copy-number variation (CNV), notably of somatic cells, is an understudied aspect of genome biology. Any differences in the genetic makeup between twins derived from the same zygote represent an irrefutable example of somatic mosaicism. We studied 19 pairs of monozygotic twins with either concordant or discordant phenotype by using two platforms for genome-wide CNV analyses and showed that CNVs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA

Share to Genetic Variation

Share to Genomic variations and chromosomal abnormalities

Share to Neurodegenerative Diseases

Share to Oligonucleotide Array Sequence Analysis

Share to Phenotype

Share to Twins, Monozygotic

Source

Open in PubMed Open full text

Identifiers

PMID: 18304490
DOI: 10.1016/j.ajhg.2007.12.011
PMCID: PMC2427204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles.PMID 18304490Read ↗

Large Autosomal Copy-Number Differences within Unselected Monozygotic Twin Pairs are Rare.Semantic proximity Read ↗

Differences in Copy Number Variation between Discordant Monozygotic Twins as a Model for Exploring Chromosomal Mosaicism in Congenital Heart DefectsSemantic proximity Read ↗

Somatic mosaicism for copy-neutral loss of heterozygosity and DNA copy number variations in the human genome.Semantic proximity Read ↗

Analysis of copy number variants in 11 pairs of monozygotic twins with neurofibromatosis type 1.Semantic proximity Read ↗

CNVs and genetic medicine (excitement and consequences of a rediscovery).Semantic proximity Read ↗

The Human Genome Puzzle &#x2014; the Role of Copy Number Variation in Somatic MosaicismSemantic proximity Read ↗

DNA copy number variation: Main characteristics, evolutionary significance, and pathological aspectsSemantic proximity Read ↗

One CNV Discordance in NRXN1 Observed Upon Genome-wide Screening in 38 Pairs of Adult Healthy Monozygotic Twins.Semantic proximity Read ↗

Copy number variation: new insights in genome diversity.Semantic proximity Read ↗

The clinical context of copy number variation in the human genome.Semantic proximity Read ↗

Copy number variation in human health, disease, and evolution.Semantic proximity Read ↗

Patterns of mosaicism for sequence and copy-number variants discovered through clinical deep sequencing of disease-related genes in one million individuals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.