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Article

Rapid and convergent evolution in the glioblastoma multiforme genome.

Genomics - 1 Mar 2015

Shpak Max, Goldberg Marcus M, Cowperthwaite Matthew C

Abstract excerpt

Determining which mutations drive tumor progression is a defining question in cancer genomics. We analyzed sequence evolution in Glioblastoma multiforme (GBM) by computing the number of parallel mutations and by estimating ω=dN/dS, a measure of the strength and direction of selection. The ω values of almost all 7617 mutated genes in GBM are much higher than in germline genes. We identified only 21 genes under...

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PMID: 25576655
DOI: 10.1016/j.ygeno.2014.12.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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