Article
Identifying bifurcated paths with differential function impact in glioblastomas evolution.
International journal of cancer - 1 Dec 2020
Zhang Yong, Xie Aimin, Quan Fei, Hou Xiaobo, Liao Jianlong, Zhu Shiwei, Pang Lin, Liang Xin, Zhu Xiaojing, Cheng Peng, Li Xia, Xiao Yun
Abstract excerpt
The evolutionary dynamics of human cancers has been investigated popularly and several bifurcated paths in cancer evolutionary trajectories are revealed to be with differential outcomes and phenotypes. However, whether such bifurcated paths exist in glioblastoma (GBM) remains unclear. In 385 GBM samples, through determining the clonal status of cancer driver events and inferring their temporal order, we...
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