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Article

Correlating structural and energetic changes in glycine receptor activation.

The Journal of biological chemistry - 27 Feb 2015

Scott Suzanne, Lynch Joseph W, Keramidas Angelo

Abstract excerpt

Pentameric ligand-gated ion channels (pLGICs) mediate fast chemoelectrical transduction in the nervous system. The mechanism by which the energy of ligand binding leads to current-conducting receptors is poorly understood and may vary among family members. We addressed these questions by correlating the structural and energetic mechanisms by which a naturally occurring M1 domain mutation (α1(Q-26'E)) enhances...

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Identifiers

PMID: 25572390
DOI: 10.1074/jbc.M114.616573
PMCID: PMC4342475

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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