Cross-subunit Interactions that Stabilize Open States Mediate Gating in NMDA Receptors

Abstract excerpt

<h4>ABSTRACT</h4> NMDA receptors are excitatory channels with critical functions in the physiology of central synapses. Their activation reaction proceeds as a series of kinetically distinguishable, reversible steps, whose structural bases are of current interest. Very likely, the earliest steps in the activation reaction include glutamate binding to and compression of the ligand-binding domain. Later, three shor...

Topics

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• Amino Acid Motifs
• Calcium
• Electrophysiological Phenomena
• Ion Channel Gating
• Mice, Neurologic Mutants
• Phenotype
• Protein Subunits
• Receptors, N-Methyl-D-Aspartate

Identifiers and source

Literature Corpus work

682386be-915b-54c3-b148-1e34ca003320

DOI

10.1101/2020.06.08.140525