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Article

Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation.

Proceedings of the National Academy of Sciences of the United States of America - 27 Apr 2010

Todorovic Jelena, Welsh Brian T, Bertaccini Edward J, Trudell James R, Mihic S John

Abstract excerpt

Proper regulation of neurotransmission requires that ligand-activated ion channels remain closed until agonist binds. How channels then open remains poorly understood. Glycine receptor (GlyR) gating is initiated by agonist binding at interfaces between adjacent subunits in the extracellular domain. Aspartate-97, located at the alpha1 GlyR interface, is a conserved residue in the cys-loop receptor superfamily. The...

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Identifiers

PMID: 20385800
DOI: 10.1073/pnas.1001845107
PMCID: PMC2867890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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