Article
Mutations in CypA Binding Region of HIV-1 Capsid Affect Capsid Stability and Viral Replication in Primary Macrophages.
AIDS research and human retroviruses - 1 Apr 2016
Setiawan Laurentia C, van Dort Karel A, Rits Maarten A N, Kootstra Neeltje A
Abstract excerpt
Mutations in the cyclophilin A (CypA) binding region in the HIV-1 capsid affect their dependency on the known HIV-1 cofactor CypA and allow escape from the HIV-1 restriction factor Trim5α in human and simian cells. Here we study the effect of these mutations in the CypA binding region of capsid on cofactor binding, capsid destabilization, and viral replication in primary cells. We showed that the viral capsid...
Topics
- Binding Sites
- Cells, Cultured
- Cyclophilin A
- HIV-1
- Humans
- Macrophages
- Mutation
- Protein Binding
- Virus Replication
- gag Gene Products, Human Immunodeficiency Virus