Article
Efficient transduction of simian cells by HIV-1-based lentiviral vectors that contain mutations in the capsid protein.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 May 2007
Rits Maarten A N, van Dort Karel A, Münk Carsten, Meijer Alexander B, Kootstra Neeltje A
Abstract excerpt
Recently, the cyclophilin A (CyPA)-binding region of the HIV-1 capsid protein was identified as a viral determinant involved in the post-entry restriction in Old World monkey cells. Here, we constructed a panel of HIV-1-based lentiviral vectors (LVs) that contain either mutations in the CyPA-binding region or the CyPA-binding region of the related viruses HIV-1 group O and HIV-2. We demonstrated that amino-acid...
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