Article
Genetic association of CD247 (CD3ζ) with SLE in a large-scale multiethnic study.
Genes and immunity - 1 Mar 2015
Martins M, Williams A H, Comeau M, Marion M, Ziegler J T, Freedman B I, Merrill J T, Glenn S B, Kelly J A, Sivils K M, James J A, Guthridge J M, Alarcón-Riquelme M E, Bae S-C, Kim J-H, Kim D, Anaya J-M, Boackle S A, Criswell L A, Kimberly R P, Alarcón G S, Brown E E, Vilá L M, Petri M A, Ramsey-Goldman R, Niewold T B, Tsao B P, Gilkeson G S, Kamen D L, Jacob C O, Stevens A M, Gaffney P M, Harley J B, Langefeld C D, Fesel C
Abstract excerpt
A classic T-cell phenotype in systemic lupus erythematosus (SLE) is the downregulation and replacement of the CD3ζ chain that alters T-cell receptor signaling. However, genetic associations with SLE in the human CD247 locus that encodes CD3ζ are not well established and require replication in independent cohorts. Our aim was therefore to examine, localize and validate CD247-SLE association in a large multiethnic...
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