Article
TCR-CD3ζ gene polymorphisms and expression profile in rheumatoid arthritis.
Autoimmunity - 1 Nov 2016
Li Peng, Wang Xiu, Zhao Meng-Qin, Li Lian-Ju, Zhang Chao, Li Bao-Zhu, Liu Juan, Yang Xiao-Ke, Leng Rui-Xue, Fan Yin-Guang, Pan Hai-Feng, Ye Dong-Qing
Abstract excerpt
OBJECTIVES: Recent evidence has demonstrated that CD3ζ (also called CD247) play a vital role in multiple autoimmune diseases. In this study, we explored the association between CD247 gene single-nucleotide polymorphisms (SNPs) and rheumatoid arthritis (RA) in a Chinese Han population. We also evaluated the CD3ζ expression profile in peripheral blood mononuclear cells (PBMCs) from patients with RA and health...
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