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Article

A simple genotyping method for CD247 3'-untranslated region polymorphism rs1052231 and characterization of a reference cell panel.

HLA - 1 Sept 2021

Al-Akioui-Sanz Karima, Moraru Manuela, Vilches Carlos

Abstract excerpt

CD247 (or CD3-ζ chain) is an essential adaptor and signal-transducing molecule of the T-cell antigen receptor (TCR) complex, and it also couples to NK-cell activating receptors such as NKp46, NKp30 and CD16A (FcγRIII). Noncoding sequence polymorphisms and variations in CD247 expression, a tightly regulated process, have been related with an altered immune response in multiple health conditions. A single...

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PMID: 34233083
DOI: 10.1111/tan.14361
PMCID: PMC9291556

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