Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD3 ζ defects in systemic lupus erythematosus.

Annals of the rheumatic diseases - 1 Apr 2012

Takeuchi Tsutomu, Suzuki Katsuya, Kondo Tsuneo, Yoshimoto Keiko, Tsuzaka Kensei

Abstract excerpt

The prototype autoimmune disease, systemic lupus erythematosus (SLE), has been known to be associated with deficiency of ζ chain, a component of the T-cell receptor-CD3 complex. Comprehensive analysis has shown that expression of the CD3 ζ chain is attenuated or absent in over half of SLE patients. Furthermore, aberrant transcripts of the CD3 ζ chain, including spliced variants lacking exon 7 or having a short...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD3 Complex
Share to Disease Models, Animal
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lupus Erythematosus, Systemic

Share to Polymorphism, Single Nucleotide

Share to Protein Isoforms

Share to Signal Transduction

Source

Identifiers

PMID: 22460144
DOI: 10.1136/annrheumdis-2011-200641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD3 ζ defects in systemic lupus erythematosus.PMID 22460144Read ↗

Genetic association of CD247 (CD3ζ) with SLE in a large-scale multiethnic study.Semantic proximity Read ↗

CD247 variants and single-nucleotide polymorphisms observed in systemic lupus erythematosus patients.Semantic proximity Read ↗

Downregulation of CD3ζ in NK Cells from Systemic Lupus Erythematosus Patients Confers a Proinflammatory Phenotype.Semantic proximity Read ↗

Patients with CD3G mutations reveal a role for human CD3γ in Treg diversity and suppressive function.Semantic proximity Read ↗

Polymorphisms in the CD3Z gene influence TCRzeta expression in systemic lupus erythematosus patients and healthy controls.Semantic proximity Read ↗

Association of CD247 with systemic lupus erythematosus in Asian populations.Semantic proximity Read ↗

CD3 deficiencies.Semantic proximity Read ↗

[CD3 subunit deficiencies].Semantic proximity Read ↗

Polymorphisms/mutations of TCR-zeta-chain promoter and 3' untranslated region and selective expression of TCR zeta-chain with an alternatively spliced 3' untranslated region in patients with systemic lupus erythematosus.Semantic proximity Read ↗

The CD3Z 844 T>A polymorphism within the 3'-UTR of CD3Z confers increased risk of incidence of systemic lupus erythematosus.Semantic proximity Read ↗

TCRzeta mRNA splice variant forms observed in the peripheral blood T cells from systemic lupus erythematosus patients.Semantic proximity Read ↗

Splicing factor SF2/ASF rescues IL-2 production in T cells from systemic lupus erythematosus patients by activating IL-2 transcriptionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.