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Article

Differential expression of sirtuin family members in the developing, adult, and aged rat brain

18 Dec 2014

Abstract excerpt

The sirtuins are NAD(+)-dependent protein deacetylases and/or ADP-ribosyltransferases that play roles in metabolic homeostasis, stress response and potentially aging. This enzyme family resides in different subcellular compartments, and acts on a number of different targets in the nucleus, cytoplasm and in the mitochondria. Despite their recognized ability to regulate metabolic processes, the roles played by...

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PMID: 25566066
DOI: 10.3389/fnagi.2014.00333

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