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Sirtuin 2 (SIRT2): Confusing Roles in the Pathophysiology of Neurological Disorders

24 May 2021

Abstract excerpt

)-dependent deacetylases, sirtuin 2 (SIRT2) is predominantly found in the cytoplasm of cells in the central nervous system (CNS), suggesting its potential role in neurological disorders. Though SIRT2 is generally acknowledged to accelerate the development of neurological pathologies, it protects the brain from deterioration in certain circumstances. This review summarized the complex roles SIRT2 plays in the...

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PMID: 34108853
DOI: 10.3389/fnins.2021.614107

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