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Expression of Sirtuins in the Retinal Neurons of Mice, Rats, and Humans

17 Nov 2017

Abstract excerpt

Sirtuins are a class of histone deacetylases (HDACs) that have been shown to regulate a range of pathophysiological processes such as cellular aging, inflammation, metabolism, and cell proliferation. There are seven mammalian Sirtuins (SIRT1-7) that play important roles in stress response, aging, and neurodegenerative diseases. However, the location and function of Sirtuins in neurons are not well defined. This...

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PMID: 29249955
DOI: 10.3389/fnagi.2017.00366

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