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Article

Zebrafish as a Model Organism to Evaluate Drugs Potentially Able to Modulate Sirtuin Expression

1 Mar 2011

Abstract excerpt

Sirtuins comprise a unique class of NAD(+)-dependent deacetylases that are key regulators of many physiological processes. They appear to be a potential target set of enzymes for treatment of age-associated diseases and have attracted interest in many research areas involving chemical and cellular investigations to understand them and discover potential ligands. For molecular screening, a cost-effective, easily...

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PMID: 21413868
DOI: 10.1089/zeb.2010.0677

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