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Article

Age-dependent tissue expression patterns of Sirt1 in senescence-accelerated mice

15 Oct 2014

Abstract excerpt

Sirtuin 1 (Sirt1) has a range of molecular functions and has emerged as an important protein in aging and metabolic regulations. Studies have reported a correlation between disturbance of Sirt1 activity and the onset of aging‑ or obesity‑associated diseases, including diabetes, cardiovascular disease and neurodegenerative disorders. However, a systematic investigation to examine the changes of Sirt1 expression in...

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PMID: 25323555
DOI: 10.3892/mmr.2014.2648

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