Article
Converging evidence for the association of functional genetic variation in the serotonin receptor 2a gene with prefrontal function and olanzapine treatment.
JAMA psychiatry - 1 Sept 2013
Blasi Giuseppe, De Virgilio Caterina, Papazacharias Apostolos, Taurisano Paolo, Gelao Barbara, Fazio Leonardo, Ursini Gianluca, Sinibaldi Lorenzo, Andriola Ileana, Masellis Rita, Romano Raffaella, Rampino Antonio, Di Giorgio Annabella, Lo Bianco Luciana, Caforio Grazia, Piva Francesco, Popolizio Teresa, Bellantuono Cesario, Todarello Orlando, Kleinman Joel E, Gadaleta Gemma, Weinberger Daniel R, Bertolino Alessandro
Abstract excerpt
IMPORTANCE: Serotonin (5-hydroxytryptamine) receptor 2a (5-HT2AR) signaling is important for modulation of corticostriatal pathways and prefrontal activity during cognition. Furthermore, newer antipsychotic drugs target 5-HT2AR. A single-nucleotide polymorphism in the 5-HT2AR gene (HTR2A rs6314, C>T; OMIM 182135) has been weakly associated with differential 5-HT2AR signaling and with physiologic as well as...
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