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Article

Phospholamban pentamers attenuate PKA-dependent phosphorylation of monomers.

Journal of molecular and cellular cardiology - 1 Mar 2015

Wittmann Tanja, Lohse Martin J, Schmitt Joachim P

Abstract excerpt

Phospholamban (PLN) is a key regulator of cardiac contraction and relaxation through its inhibition of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA2a). The inhibitory effect is attenuated upon protein kinase A (PKA) dependent phosphorylation of PLN. PLN exists in an equilibrium of pentamers and monomers. While monomers inhibit SERCA2a by direct interaction, the function of the pentamers is still unclear....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25562800
DOI: 10.1016/j.yjmcc.2014.12.020

Genes

PLN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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