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Article

Allosteric regulation of SERCA by phosphorylation-mediated conformational shift of phospholamban.

Proceedings of the National Academy of Sciences of the United States of America - 22 Oct 2013

Gustavsson Martin, Verardi Raffaello, Mullen Daniel G, Mote Kaustubh R, Traaseth Nathaniel J, Gopinath T, Veglia Gianluigi

Abstract excerpt

The membrane protein complex between the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) and phospholamban (PLN) controls Ca(2+) transport in cardiomyocytes, thereby modulating cardiac contractility. β-Adrenergic-stimulated phosphorylation of PLN at Ser-16 enhances SERCA activity via an unknown mechanism. Using solid-state nuclear magnetic resonance spectroscopy, we mapped the physical interactions between SERCA and...

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Identifiers

PMID: 24101520
DOI: 10.1073/pnas.1303006110
PMCID: PMC3808617

Genes

PLN

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Allosteric regulation of SERCA by phosphorylation-mediated conformational shift of phospholamban.PMID 24101520Read ↗

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