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Article

Phosphorylation and mutation of phospholamban alter physical interactions with the sarcoplasmic reticulum calcium pump.

Journal of molecular biology - 21 Jan 2011

Glaves John Paul, Trieber Catharine A, Ceholski Delaine K, Stokes David L, Young Howard S

Abstract excerpt

Phospholamban physically interacts with the sarcoplasmic reticulum calcium pump (SERCA) and regulates contractility of the heart in response to adrenergic stimuli. We studied this interaction using electron microscopy of 2D crystals of SERCA in complex with phospholamban. In earlier studies, phospholamban oligomers were found interspersed between SERCA dimer ribbons and a 3D model was constructed to show...

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Identifiers

PMID: 21108950
DOI: 10.1016/j.jmb.2010.11.014
PMCID: PMC3121535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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