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Article

Molecular noise filtering in the β-adrenergic signaling network by phospholamban pentamers.

Cell reports - 27 Jul 2021

Koch Daniel, Alexandrovich Alexander, Funk Florian, Kho Ay Lin, Schmitt Joachim P, Gautel Mathias

Abstract excerpt

Phospholamban (PLN) is an important regulator of cardiac calcium handling due to its ability to inhibit the calcium ATPase SERCA. β-Adrenergic stimulation reverses SERCA inhibition via PLN phosphorylation and facilitates fast calcium reuptake. PLN also forms pentamers whose physiological significance has remained elusive. Using mathematical modeling combined with biochemical and cell biological experiments, we...

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Identifiers

PMID: 34320358
DOI: 10.1016/j.celrep.2021.109448
PMCID: PMC8333238

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