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Article

Phosphomimetic mutations increase phospholamban oligomerization and alter the structure of its regulatory complex.

The Journal of biological chemistry - 24 Oct 2008

Hou Zhanjia, Kelly Eileen M, Robia Seth L

Abstract excerpt

To investigate the effect of phosphorylation on the interactions of phospholamban (PLB) with itself and its regulatory target, SERCA, we measured FRET from CFP-SERCA or CFP-PLB to YFP-PLB in live AAV-293 cells. Phosphorylation of PLB was mimicked by mutations S16E (PKA site) or S16E/T17E (PKA+CaM...

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Identifiers

PMID: 18708665
DOI: 10.1074/jbc.M804782200
PMCID: PMC2570860

Genes

CFP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18708665-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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