Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Monomeric phospholamban overexpression in transgenic mouse hearts.

Circulation research - 1 Oct 1997

Chu G, Dorn G W, Luo W, Harrer J M, Kadambi V J, Walsh R A, Kranias E G

Abstract excerpt

Phospholamban, a prominent modulator of the sarcoplasmic reticulum (SR) Ca(2+)-ATPase activity and basal contractility in the mammalian heart, has been proposed to form pentamers in native SR membranes. However, the monomeric form of phospholamban, which is associated with mutating Cys41 to Phe41...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Calcium-Binding Proteins
Share to Cell Separation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to SDS gene

Share to Mice, Transgenic

Share to Mutation

Share to Myocardium

Source

Identifiers

PMID: 9314829
DOI: 10.1161/01.res.81.4.485

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9314829-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Monomeric phospholamban overexpression in transgenic mouse hearts.PMID 9314829Read ↗

The enhanced contractility of the phospholamban-deficient mouse heart persists with aging.Semantic proximity Read ↗

Sarcoplasmic reticulum Ca-ATPase-phospholamban interactions and dilated cardiomyopathy.Semantic proximity Read ↗

Early consequences of the phospholamban mutation PLN-R14del+/- in a transgenic mouse model.Semantic proximity Read ↗

Structural and functional implications of the phospholamban hinge domain: impaired SR Ca2+ uptake as a primary cause of heart failure.Semantic proximity Read ↗

Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation.Semantic proximity Read ↗

Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and humanSemantic proximity Read ↗

Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human.Semantic proximity Read ↗

Identification of biochemical adaptations in hyper- or hypocontractile hearts from phospholamban mutant mice by expression proteomics.Semantic proximity Read ↗

Chronic SR Ca2+-ATPase inhibition causes adaptive changes in cellular Ca2+ transport.Semantic proximity Read ↗

Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein.Semantic proximity Read ↗

Cardiac hypertrophy in mice expressing unphosphorylatable phospholemman.Semantic proximity Read ↗

A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.