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Article

The determinants of lifespan in the nematode Caenorhabditis elegans: a short primer.

Science progress - 1 Jan 2004

Geanacopoulos Mark

Abstract excerpt

Transparent, easily-maintained, amenable to genetic manipulation, and living for only a few weeks, the nematode Caenorhabditis elegans is a leading animal model for the study of the determinants of lifespan. The original genetic screen for increased longevity identified a mutant, age-1, with a defect in one component of a signal transduction pathway. This pathway functioned as a genetic switch and governed the...

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Identifiers

PMID: 16028834
DOI: 10.3184/003685004783238472
PMCID: PMC10367488

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Source receipt: pubmed, retrieved 7 Sept 2026.

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