Article
Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke.
Pharmacogenetics and genomics - 1 Jun 2008
Marciante Kristin D, Totah Rheem A, Heckbert Susan R, Smith Nicholas L, Lemaitre Rozenn N, Lumley Thomas, Rice Kenneth M, Hindorff Lucia A, Bis Joshua C, Hartman Brittany, Psaty Bruce M
Abstract excerpt
OBJECTIVE: The biologically active epoxyeicosatrienoic acids have protective vascular effects. CYP2J2, CYP2C8, and CYP2C9 are known to be a source of epoxyeicosatrienoic acids in cardiac tissues. We conducted a population-based, case-control study at Group Health to determine whether common genetic variation in the CYP2J2, CYP2C8, and CYP2C9 genes was associated with the risk of myocardial infarction and ischemic...
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