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Article

The CYP2J2 G-50T polymorphism and myocardial infarction in patients with cardiovascular risk profile.

BMC cardiovascular disorders - 23 Dec 2008

Börgel Jan, Bulut Daniel, Hanefeld Christoph, Neubauer Horst, Mügge Andreas, Epplen Jörg T, Holland-Letz Tim, Spiecker Martin

Abstract excerpt

BACKGROUND: Cytochrome P450 (CYP) enzyme 2J2, an epoxygenase predominantly expressed in the heart, metabolizes arachidonic acid to biologically active eicosanoids. One of the CYP2J2 products, 11, 12-epoxyeicosatrienoic acid, has several vasoprotective effects. The CYP2J2-G-50T-promotor polymorphism decreases gene expression and is associated with coronary artery disease. This association supports the vascular...

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Identifiers

PMID: 19105833
DOI: 10.1186/1471-2261-8-41
PMCID: PMC2626571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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