Article
Biased allelic expression in human primary fibroblast single cells.
American journal of human genetics - 8 Jan 2015
Borel Christelle, Ferreira Pedro G, Santoni Federico, Delaneau Olivier, Fort Alexandre, Popadin Konstantin Y, Garieri Marco, Falconnet Emilie, Ribaux Pascale, Guipponi Michel, Padioleau Ismael, Carninci Piero, Dermitzakis Emmanouil T, Antonarakis Stylianos E
Abstract excerpt
The study of gene expression in mammalian single cells via genomic technologies now provides the possibility to investigate the patterns of allelic gene expression. We used single-cell RNA sequencing to detect the allele-specific mRNA level in 203 single human primary fibroblasts over 133,633 unique heterozygous single-nucleotide variants (hetSNVs). We observed that at the snapshot of analyses, each cell...
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