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Article

A cleavage-resistant urokinase plasminogen activator receptor exhibits dysregulated cell-surface clearance.

The Journal of biological chemistry - 23 Apr 2010

Nieves Evelyn C, Manchanda Naveen

Abstract excerpt

Urokinase plasminogen activator receptor (u-PAR) binds urokinase plasminogen activator (u-PA) and participates in plasminogen activation in addition to modulating several cellular processes such as adhesion, proliferation, and migration. u-PAR is susceptible to proteolysis by its cognate ligand and several other proteases. To elucidate the biological significance of receptor cleavage by u-PA, we engineered and...

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Identifiers

PMID: 20177061
DOI: 10.1074/jbc.M109.008581
PMCID: PMC2857136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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