Article
Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22.
Blood - 15 May 2005
Yasuda Shinsuke, Morokawa Nasa, Wong G William, Rossi Andrea, Madhusudhan Mallur S, Sali Andrej, Askew Yuko S, Adachi Roberto, Silverman Gary A, Krilis Steven A, Stevens Richard L
Abstract excerpt
Tryptase epsilon is a member of the chromosome 16p13.3 family of human serine proteases that is preferentially expressed by epithelial cells. Recombinant pro-tryptase epsilon was generated to understand how the exocytosed zymogen might be activated outside of the epithelial cell, as well as to address its possible role in normal and diseased states. Using expression/site-directed mutagenesis approaches, we now...
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