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Article

The autoactivation of human single-chain urokinase-type plasminogen activator (uPA)

20 Aug 2023

Abstract excerpt

Most serine proteases are synthesized as inactive zymogens that are activated by cleavage by another protease in a tightly regulated mechanism. The urokinase-type plasminogen activator (uPA) and plasmin cleave and activate each other, constituting a positive feedback loop. How this mutual activation cycle begins has remained a mystery. We used hydrogen deuterium exchange mass spectrometry to characterize the...

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PMID: 37607618
DOI: 10.1016/j.jbc.2023.105179

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