Article
Extragenic suppressor mutations in ΔripA disrupt stability and function of LpxA.
BMC microbiology - 31 Dec 2014
Miller Cheryl N, Steele Shaun P, Brunton Jason C, Jenkins Ronald J, LoVullo Eric D, Taft-Benz Sharon A, Romanchuk Artur, Jones Corbin D, Dotson Garry D, Collins Edward J, Kawula Thomas H
Abstract excerpt
BACKGROUND: Francisella tularensis is a Gram-negative bacterium that infects hundreds of species including humans, and has evolved to grow efficiently within a plethora of cell types. RipA is a conserved membrane protein of F. tularensis, which is required for growth inside host cells. As a means to determine RipA function we isolated and mapped independent extragenic suppressor mutants in ∆ripA that restored...
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