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Article

Outer membrane vesicle-associated lipase FtlA enhances cellular invasion and virulence in Francisella tularensis LVS.

Emerging microbes & infections - 26 Jul 2017

Chen Fei, Cui Guolin, Wang Shuxia, Nair Manoj Kumar Mohan, He Lihong, Qi Xinyi, Han Xiangmin, Zhang Hanqi, Zhang Jing-Ren, Su Jingliang

Abstract excerpt

Francisella tularensis is a highly infectious intracellular pathogen that infects a wide range of host species and causes fatal pneumonic tularemia in humans. ftlA was identified as a potential virulence determinant of the F. tularensis live vaccine strain (LVS) in our previous transposon screen, but its function remained undefined. Here, we show that an unmarked deletion mutant of ftlA was avirulent in a...

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Identifiers

PMID: 28745311
DOI: 10.1038/emi.2017.53
PMCID: PMC5567169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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