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PolyGenie: a reproducible Nextflow pipeline for phenome-wide association studies using polygenic risk scores

2025-09-10

Abstract excerpt

<h4>Summary</h4> Phenome-wide association studies (PheWAS) using polygenic risk scores (PRS) offer a powerful framework for exploring the shared genetic architecture of complex traits across diverse phenotypic domains. However, no standardized, portable pipeline exists to facilitate their systematic execution and visualization in arbitrary population cohorts. We present PolyGenie, an open-source Nextflow pipeline...

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Literature Corpus work
e210e6b9-16bd-5cbf-97cf-bdf9591f8e52
DOI
10.1101/2025.09.05.674501
Open publication

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PolyGenie: a reproducible Nextflow pipeline for phenome-wide association studies using polygenic risk scoresDOI 10.1101/2025.09.05.674501
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