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Article

Nox4 is required for maintenance of the differentiated vascular smooth muscle cell phenotype.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2007

Clempus Roza E, Sorescu Dan, Dikalova Anna E, Pounkova Lily, Jo Patricia, Sorescu George P, Schmidt Harald H H, Lassègue Bernard, Griendling Kathy K

Abstract excerpt

OBJECTIVE: The mechanisms responsible for maintaining the differentiated phenotype of adult vascular smooth muscle cells (VSMCs) are incompletely understood. Reactive oxygen species (ROS) have been implicated in VSMC differentiation, but the responsible sources are unknown. In this study, we investigated the role of Nox1 and Nox4-derived ROS in this process. METHODS AND RESULTS: Primary VSMCs were used to study...

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Identifiers

PMID: 17082491
DOI: 10.1161/01.ATV.0000251500.94478.18
PMCID: PMC1868577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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