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Article

Endothelial-derived nitric oxide impacts vascular smooth muscle cell phenotypes under high wall shear stress condition.

Biochemical and biophysical research communications - 25 Dec 2024

Sawasaki Kaoru, Nakamura Masanori, Kimura Naoyuki, Kawahito Koji, Yamazaki Masashi, Fujie Hiromichi, Sakamoto Naoya

Abstract excerpt

The Phenotypic states of vascular smooth muscle cells (SMCs) are essential to understanding vascular pathophysiology. SMCs in vessels generally express a specific set of contractile proteins, but decreased contractile protein expression, indicating a phenotypic shift, is a hallmark of vascular diseases. Recent studies have suggested the relation of abnormally high wall shear stress (WSS) of approximately 20 Pa...

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PMID: 39561651
DOI: 10.1016/j.bbrc.2024.151005

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