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Article

Notch-mediated CBF-1/RBP-J{kappa}-dependent regulation of human vascular smooth muscle cell phenotype in vitro.

American journal of physiology. Cell physiology - 1 Nov 2005

Morrow David, Scheller Agnieszka, Birney Yvonne A, Sweeney Catherine, Guha Shaunta, Cummins Philip M, Murphy Ronan, Walls Dermot, Redmond Eileen M, Cahill Paul A

Abstract excerpt

Vascular smooth muscle cell (VSMC) phenotypic modulation is a key factor in vascular pathology. We have investigated the role of Notch receptor signaling in controlling human vascular smooth muscle cell (hVSMC) differentiation in vitro and established a role for cyclic strain-induced changes in Notch signaling in promoting this phenotypic response. The expression of alpha-actin, calponin, myosin, and smoothelin...

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Identifiers

PMID: 15987768
DOI: 10.1152/ajpcell.00198.2005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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