Article
Loss of the mechanotransducer zyxin promotes a synthetic phenotype of vascular smooth muscle cells.
Journal of the American Heart Association - 12 Jun 2015
Ghosh Subhajit, Kollar Branislav, Nahar Taslima, Suresh Babu Sahana, Wojtowicz Agnieszka, Sticht Carsten, Gretz Norbert, Wagner Andreas H, Korff Thomas, Hecker Markus
Abstract excerpt
BACKGROUND: Exposure of vascular smooth muscle cells (VSMCs) to excessive cyclic stretch such as in hypertension causes a shift in their phenotype. The focal adhesion protein zyxin can transduce such biomechanical stimuli to the nucleus of both endothelial cells and VSMCs, albeit with different thresholds and kinetics. However, there is no distinct vascular phenotype in young zyxin-deficient mice, possibly due to...
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