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Article

Biomechanical stretch-induced CLOCK upregulation in venous smooth muscle cells promotes phenotypic and functional transformation.

Vascular pharmacology - 1 Oct 2022

Guo Zhenyu, Zhang Wan, Li Xu, Wang Tao, Yang Xiaohu, Fan Longhua

Abstract excerpt

BACKGROUND: A chronic change in hemodynamic forces might activate the pathophysiological process of maladaptive venous remodeling. Biomechanical stretching stimulates venous smooth muscle cells (SMCs) in the media, and biomechanical loads exceeding physiological levels affect the intrinsic circadian rhythm and cellular phenotype. This study aimed to investigate the changes in the expression patterns of circadian...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35963524
DOI: 10.1016/j.vph.2022.107097

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