Article
iRhom2 mutation leads to aberrant hair follicle differentiation in mice.
PloS one - 1 Jan 2014
Leilei Yang, Bing Liu, Yang Li, Shaoxia Wang, Yuan Xu, Dongping Wang, Huahu Ye, Shichen Shang, Guangzhou Zhang, Ruiyun Peng, Lin Zeng, Wenlong Li
Abstract excerpt
iRhom1 and iRhom2 are inactive homologues of rhomboid intramembrane serine proteases lacking essential catalytic residues, which are necessary for the maturation of TNFα-converting enzyme (TACE). In addition, iRhoms regulate epidermal growth factor family secretion. The functional significance of iRhom2 during mammalian development is largely unclear. We have identified a spontaneous single gene deletion mutation...
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