Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proteomic analysis of differentially expressed skin proteins in iRhom2(Uncv) mice.

BMB reports - 1 Jan 2015

Liu Bing, Xu Yuan, Li Wen-Long, Zeng Lin

Abstract excerpt

A mouse homozygous for the spontaneous mutation uncovered (Uncv) has a hairless phenotype. A 309-bp non-frameshift deletion mutation in the N-terminal cytoplasmic domain of iRhom2 was identified in Uncv mice (iRhom2(Uncv)) using target region sequencing. The detailed molecular basis for how the iRhom2 mutation causes the hairless phenotype observed in the homozygous iRhom2(Uncv) mouse remains unknown. To identify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down-Regulation
Share to Electrophoresis, Gel, Two-Dimensional
Share to Mice, Hairless

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microfilament Proteins

Share to Proteomics

Share to Real-Time Polymerase Chain Reaction

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Open in PubMed Open full text

Identifiers

PMID: 24667173
DOI: 10.5483/bmbrep.2015.48.1.022
PMCID: PMC4345637

Genes

KRT73
MEMO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proteomic analysis of differentially expressed skin proteins in iRhom2(Uncv) mice.PMID 24667173Read ↗

iRhom2 mutation leads to aberrant hair follicle differentiation in mice.Semantic proximity Read ↗

iRhom2 (Uncv) mutation blocks bulge stem cells assuming the fate of hair follicle.Semantic proximity Read ↗

Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.Semantic proximity Read ↗

Distinguishing mouse strains by proteomic analysis of pelage hair.Semantic proximity Read ↗

Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.Semantic proximity Read ↗

Differentiating inbred mouse strains from each other and those with single gene mutations using hair proteomics.Semantic proximity Read ↗

Cutaneous transcriptome analysis in NIH hairless mice.Semantic proximity Read ↗

Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activity.Semantic proximity Read ↗

Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activitySemantic proximity Read ↗

Autosomal-dominant woolly hair resulting from disruption of keratin 74 (KRT74), a potential determinant of human hair texture.Semantic proximity Read ↗

Morphologic and molecular characterization of two novel Krt71 (Krt2-6g) mutations: Krt71rco12 and Krt71rco13.Semantic proximity Read ↗

Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.