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Article

iRhom2 (Uncv) mutation blocks bulge stem cells assuming the fate of hair follicle.

Archives of dermatological research - 1 Sept 2016

Yang Leilei, Li Wenlong, Liu Bing, Wang Shaoxia, Zeng Lin, Zhang Cuiping, Li Yang

Abstract excerpt

iRhom2 is necessary for maturation of TNFα-converting enzyme, which is required for the release of tumor necrosis factor. In the previous study, we found that the iRhom2 (Uncv) mutation in N-terminal cytoplasmic domain-encoding region (iRhom2 (Uncv) ) leads to aberrant hair shaft and inner root sheath differentiation, thus results in a hairless phenotype in homozygous iRhom2 (Uncv/Uncv) BALB/c mice. In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27393687
DOI: 10.1007/s00403-016-1663-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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