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A Quantitative Proteomics Tool To Identify DNA–Protein Interactions in Primary Cells or Blood

29 Dec 2014

Abstract excerpt

Interactions between transcription factors and genomic DNA, and in particular their impact on disease and cell fate, have been extensively studied on a global level using techniques based on next-generation sequencing. These approaches, however, do not allow an unbiased study of protein complexes that bind to certain DNA sequences. DNA pulldowns from crude lysates combined with quantitative mass spectrometry were...

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PMID: 25546135
DOI: 10.1021/pr5009515

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