Article
Identification of covalent modifications regulating immune signaling complex composition and phenotype.
Molecular systems biology - 1 Jul 2021
Frauenstein Annika, Ebner Stefan, Hansen Fynn M, Sinha Ankit, Phulphagar Kshiti, Swatek Kirby, Hornburg Daniel, Mann Matthias, Meissner Felix
Abstract excerpt
Cells signal through rearrangements of protein communities governed by covalent modifications and reversible interactions of distinct sets of proteins. A method that identifies those post-transcriptional modifications regulating signaling complex composition and functional phenotypes in one experimental setup would facilitate an efficient identification of novel molecular signaling checkpoints. Here, we devised...
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