Article

Transcriptome-wide high-throughput mapping of protein-RNA occupancy profiles using POP-seq

2020-12-28

Abstract excerpt

Interaction between proteins and RNA is critical for post-transcriptional regulatory processes. Existing high throughput methods based on crosslinking of the protein-RNA complexes and polyA pull down are reported to contribute to biases and are not readily amenable for identifying interaction sites on non polyA RNAs. We present Protein Occupancy Profile-Sequencing (POP-seq), a phase separation based method in thre...

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Literature Corpus work: 8026a9c0-3a40-57dd-8756-fbef8764a376
DOI: 10.1101/2020.12.28.424570

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